Drug Selectivity: An Evolving Concept in Medicinal Chemistry (Methods and Principles in Medicinal Chemistry) ()

Drug Selectivity: An Evolving Concept in Medicinal Chemistry (Methods and Principles in Medicinal Chemistry) ()

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Drug Selectivity: An Evolving Concept in Medicinal Chemistry (Methods and Principles in Medicinal Chemistry) ()

by Norbert Handler (Editor),‎ Helmut Buschmann (Series Editor),‎ Raimund Mannhold (Series Editor),‎ Jörg Holenz (Series Editor) & 1 more

by Norbert Handler (Editor),‎ Helmut Buschmann (Series Editor),‎ Raimund Mannhold (Series Editor),‎ Jörg Holenz (Series Editor) & 1 more

In the ever-evolving field of medicinal chemistry, researchers are continuously exploring new strategies to develop drugs that can target multiple diseases or conditions simultaneously. The book “Multiple Ligand Approaches in Drug Design: Towards Selective Pharmacology” provides a comprehensive compilation and current overview of these multiple ligand approaches in drug design. Edited by Norbert Handler, with contributions from leading experts in the field, this book offers valuable insights into the effects of aiming for multiple targets on the entire drug development process.

The main focus of this book is to present various design approaches and discovery technologies that can be employed to develop selective drugs. It explores the theoretical and practical aspects of multiple ligand approaches, showcasing successful examples taken from major disease areas. This handbook is an essential resource for medicinal and pharmaceutical chemists who are interested in staying up-to-date with the emerging paradigm of drug development.

One of the key themes discussed in the book is the concept of drug selectivity. Traditionally, drug development has focused on targeting a single molecular target, typically a protein or an enzyme, with the aim of achieving therapeutic efficacy. However, this approach often leads to limited efficacy or adverse side effects. The multiple ligand approach offers a new perspective by targeting multiple molecular targets simultaneously, leading to improved therapeutic outcomes and reduced side effects.

The book highlights various strategies and technologies that can be employed to develop selective drugs. These include the exploration of chemical space, the design of multi-target-directed ligands, and the merging of multiple ligands. The authors also discuss the use of computational methods and high-throughput screening to identify compounds with multi-target activity. Additionally, the book presents case studies from different disease areas, such as cancer, neurodegenerative diseases, and infectious diseases, to demonstrate the effectiveness of the multiple ligand approach.

Product Details

  • Series: Methods and Principles in Medicinal Chemistry
  • eBook Digital: 536 pages
  • Publisher: Wiley-VCH; 1 edition (February 27, 2018)
  • Language: English
  • ISBN-10: 3527335382
  • ISBN-13: 978-3527335381
  • Product Dimensions: 6.7 x 6.7 x 9.4 inches

With its wide-ranging view of an emerging new paradigm in drug development, “Multiple Ligand Approaches in Drug Design: Towards Selective Pharmacology” is an essential reference for medicinal and pharmaceutical chemists. The book not only provides insights into the theoretical aspects of multiple ligand approaches but also practical strategies and technologies that can be implemented in drug development. The case studies presented in the book demonstrate the effectiveness of the multiple ligand approach in various disease areas, further highlighting the potential of this approach in improving therapeutic outcomes.

One of the key advantages of the multiple ligand approach is the potential to overcome the limitations of traditional single-target drug development. By targeting multiple molecular targets, researchers can develop drugs that exhibit improved efficacy and reduced side effects. This approach is particularly promising for complex diseases where multiple molecular targets are involved.

The book delves into different design approaches that can be used to develop selective drugs. It explores the exploration of chemical space, which involves screening large libraries of compounds to identify molecules with desired properties. The design of multi-target-directed ligands is also discussed, which involves designing compounds that can interact with multiple targets simultaneously. Additionally, the book explores the merging of multiple ligands, where multiple compounds are merged into a single molecule to achieve selectivity.

Computational methods and high-throughput screening are valuable tools in the multiple ligand approach. These methods allow researchers to efficiently screen large libraries of compounds and predict their multi-target activity. The book discusses the use of these methods in drug discovery and provides examples of successful applications.

Furthermore, the book presents case studies from different disease areas to illustrate the potential of the multiple ligand approach. It showcases success stories in the development of selective drugs for cancer, neurodegenerative diseases, and infectious diseases. These case studies provide valuable insights into the practical application of the multiple ligand approach and highlight its potential for impacting patient care.

With its comprehensive coverage and practical insights, “Multiple Ligand Approaches in Drug Design: Towards Selective Pharmacology” is a valuable resource for medicinal and pharmaceutical chemists. The book offers an in-depth understanding of the theoretical and practical aspects of the multiple ligand approach, helping researchers stay at the forefront of drug development.

Order your copy of “Multiple Ligand Approaches in Drug Design: Towards Selective Pharmacology” today and explore the cutting-edge strategies and technologies in drug development. Join the global community of medicinal and pharmaceutical chemists who are embracing the multiple ligand approach to develop selective drugs with improved therapeutic outcomes. Start your journey towards advancing patient care and making a lasting impact in the field of medicinal chemistry.

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