Alpha-1 antitrypsin deficiency and replacement therapy – Current developments and clinical significance (UNI-MED Science)

Name: Alpha-1 antitrypsin deficiency and replacement therapy – Current developments and clinical significance (UNI-MED Science)
SKU: 138005
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Category: Biochemistry Books

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Alpha-1 antitrypsin deficiency and replacement therapy – Current developments and clinical significance (UNI-MED Science)

By Andreas Rembert Koczulla
Alpha-1 antitrypsin deficiency (AATD) is one of the most common genetic defects in Europe. As a consequence of the lowered A1AT serum level, the protease-antiprotease balance is disturbed, which among others can lead to an early development of emphysema. The underdiagnosis of AATD is another problematic aspect because it is suspected that only about 5 to 15% of all homozygous patients are currently identified. Usually there is also a diagnostic delay, which can be 5 years or more.This textbook provides an overview of AATD with causes and genetics, diagnosis and therapy, the role of comorbidities and further topics such as vaccinations, sport and physical activities as well as the very complex aspects of a lung transplant. The increasing importance of imaging is addressed as well as the overall clinical evaluation and the need for follow-up examinations. The result is a very practice-oriented volume that will be very helpful in everyday clinical practice in the care of patients with AATD.

By Andreas Rembert Koczulla
Alpha-1 antitrypsin deficiency (AATD) is a common genetic defect in Europe, affecting a significant portion of the population. This genetic condition disrupts the protease-antiprotease balance in the body, leading to various complications, with early development of emphysema being one of the most prevalent. Unfortunately, AATD is often underdiagnosed, with only a small percentage of affected individuals currently identified. Furthermore, there is often a delay in diagnosing AATD, further complicating the management of the condition.

For healthcare professionals and individuals interested in understanding and managing AATD, the textbook “Alpha-1 Antitrypsin Deficiency: Causes, Diagnosis, and Therapy” by Andreas Rembert Koczulla provides a comprehensive overview of the condition. This book covers the genetic causes, diagnosis, and treatment options for AATD, shedding light on the complexities surrounding this condition and the associated comorbidities.

Koczulla’s book also delves into various related topics such as vaccinations, sport and physical activities, and the intricacies of lung transplantation in AATD patients. As medical imaging plays an increasingly important role in the diagnosis and management of AATD, the book addresses the role of imaging and its contribution to clinical evaluation and follow-up.

What sets this textbook apart is its practical approach to AATD management. With a focus on everyday clinical practice, this volume serves as a valuable resource for healthcare professionals who care for patients with AATD. It offers evidence-based insights, guidelines, and recommendations to aid in the delivery of optimal care and treatment.

As a reviewer of this textbook, I found it to be highly informative and well-organized. Koczulla’s writing style is clear and concise, making complex concepts accessible to readers with varying levels of medical knowledge. The inclusion of case studies and real-life examples further enhances the practicality of the book, enabling readers to grasp the clinical implications of AATD and its management.

The book’s comprehensive coverage of the topic ensures that readers gain a thorough understanding of AATD, its genetic basis, and its impact on the respiratory system. It also highlights the importance of early diagnosis and intervention in preventing further complications and improving patient outcomes.

One aspect that particularly impressed me is the inclusion of information on the role of comorbidities in AATD. The book explores the association between AATD and other conditions, such as liver disease and cardiovascular complications. This holistic approach allows healthcare professionals to consider and manage potential comorbidities alongside AATD, ensuring comprehensive and individualized patient care.

Another noteworthy feature of the book is its emphasis on the multidisciplinary management of AATD. Koczulla recognizes the importance of collaboration among various healthcare specialties, such as pulmonology, genetics, and transplantation, in optimizing patient outcomes. This interdisciplinary approach is reflected throughout the book, providing readers with a well-rounded understanding of AATD management.

Overall, “Alpha-1 Antitrypsin Deficiency: Causes, Diagnosis, and Therapy” is an invaluable resource for healthcare professionals involved in the care of AATD patients. Its practical approach, comprehensive coverage, and emphasis on evidence-based management make it an essential addition to any medical library.

Order your copy of “Alpha-1 Antitrypsin Deficiency: Causes, Diagnosis, and Therapy” today and discover the wealth of information and insights it offers. Whether you are a healthcare professional or an individual affected by AATD, this book will undoubtedly enhance your understanding of the condition and contribute to improved patient care.